The current Vleeshuis was built between 1460 and 1462 on the same site as its predecessor from 1293. On the ground floor was the hall for the local butchers, who were only allowed to sell their meat products here to private individuals.
Over the centuries, the Vleeshuis has served as a meat and cloth hall, aldermen's house, four scissors, prison, guild room, theater and guardroom. In 1862 the last 'meat banks' disappeared and the space was transformed into a covered vegetable market. At the end of the 19th century, the building was thoroughly restored by Edouard Bouwens. Since 1899, the Vleeshuis has functioned as an archaeological museum. In 1914 it narrowly escaped a fire and in 1943 it was protected as a monument.
In the current Vleeshuis Museum, visitors walk through the history of Dendermonde, with prehistory as the starting point and the end of the ancien régime.